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Prostate Cancer Lung Metastasis: Clinical Insights and Therapeutic Strategies.

Authors :
Mahmoud AM
Moustafa A
Day C
Ahmed ME
Zeina W
Marzouk UM
Basourakos S
Haloi R
Mahon M
Muniz M
Childs DS
Orme JJ
Riaz IB
Kendi AT
Stish BJ
Davis BJ
Kwon ED
Andrews JR
Source :
Cancers [Cancers (Basel)] 2024 May 30; Vol. 16 (11). Date of Electronic Publication: 2024 May 30.
Publication Year :
2024

Abstract

Prostate cancer lung metastasis represents a clinical conundrum due to its implications for advanced disease progression and the complexities it introduces in treatment planning. As the disease progresses to distant sites such as the lung, the clinical management becomes increasingly intricate, requiring tailored therapeutic strategies to address the unique characteristics of metastatic lesions. This review seeks to synthesize the current state of knowledge surrounding prostate cancer metastasis to the lung, shedding light on the diverse array of clinical presentations encountered, ranging from subtle radiological findings to overt symptomatic manifestations. By examining the diagnostic modalities utilized in identifying this metastasis, including advanced imaging techniques and histopathological analyses, this review aims to provide insights into the diagnostic landscape and the challenges associated with accurately characterizing lung metastatic lesions in prostate cancer patients. Moreover, this review delves into the nuances of therapeutic interventions employed in managing prostate cancer lung metastasis, encompassing systemic treatments such as hormonal therapies and chemotherapy, as well as metastasis-directed therapies including surgery and radiotherapy.

Details

Language :
English
ISSN :
2072-6694
Volume :
16
Issue :
11
Database :
MEDLINE
Journal :
Cancers
Publication Type :
Academic Journal
Accession number :
38893199
Full Text :
https://doi.org/10.3390/cancers16112080