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Management of Arrhythmias and Conduction Disorders in Amyloid Cardiomyopathy.

Authors :
Holcman K
Ząbek A
Boczar K
Podolec P
Kostkiewicz M
Source :
Journal of clinical medicine [J Clin Med] 2024 May 24; Vol. 13 (11). Date of Electronic Publication: 2024 May 24.
Publication Year :
2024

Abstract

Cardiac amyloidosis, a condition characterized by abnormal protein deposition in the heart, leads to restrictive cardiomyopathy and is notably associated with an increased risk of arrhythmias and conduction disorders. This article reviews the current understanding and management strategies for these cardiac complications, with a focus on recent advancements and clinical challenges. The prevalence and impact of atrial arrhythmias, particularly atrial fibrillation, are examined, along with considerations for stroke risk and anticoagulation therapy. The article also addresses the complexities of managing rate and rhythm control, outlining the utility and limitations of pharmacological agents and interventions such as catheter ablation. Furthermore, it reviews the challenges in the treatment of ventricular arrhythmias, including the contentious use of implantable cardioverter-defibrillators for primary and secondary prevention. Individualized approaches, considering the unique characteristics of cardiac amyloidosis, are paramount. Continuous research and clinical exploration are essential to refine treatment strategies and improve outcomes in this challenging patient population.

Details

Language :
English
ISSN :
2077-0383
Volume :
13
Issue :
11
Database :
MEDLINE
Journal :
Journal of clinical medicine
Publication Type :
Academic Journal
Accession number :
38892799
Full Text :
https://doi.org/10.3390/jcm13113088