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Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 May 29; Vol. 25 (11). Date of Electronic Publication: 2024 May 29. - Publication Year :
- 2024
-
Abstract
- Thymic stromal lymphopoietin (TSLP), is a protein belonging to a class of epithelial cytokines commonly called alarmins, which also includes IL-25 and IL-33. Functionally, TSLP is a key player in the immune response to environmental insults, initiating a number of downstream inflammatory pathways. TSLP performs its role by binding to a high-affinity heteromeric complex composed of the thymic stromal lymphopoietin receptor (TSLPR) chain and IL-7Rα. In recent years, the important role of proinflammatory cytokines in the etiopathogenesis of various chronic diseases such as asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), chronic obstructive pulmonary diseases (COPDs), and chronic spontaneous urticaria has been studied. Although alarmins have been found to be mainly implicated in the mechanisms of type 2 inflammation, studies on monoclonal antibodies against TSLP demonstrate partial efficacy even in patients whose inflammation is not definable as T2 and the so-called low T2. Tezepelumab is a human anti-TSLP antibody that prevents TSLP-TSLPR interactions. Several clinical trials are evaluating the safety and efficacy of Tezepelumab in various inflammatory disorders. In this review, we will highlight major recent advances in understanding the functional role of TSLP, its involvement in Th2-related diseases, and its suitability as a target for biological therapies.
- Subjects :
- Humans
Animals
Receptors, Cytokine metabolism
Receptors, Cytokine antagonists & inhibitors
Molecular Targeted Therapy
Respiratory Tract Diseases drug therapy
Respiratory Tract Diseases metabolism
Asthma drug therapy
Asthma metabolism
Cytokines metabolism
Thymic Stromal Lymphopoietin
Antibodies, Monoclonal, Humanized therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38892164
- Full Text :
- https://doi.org/10.3390/ijms25115972