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Hyaluronic Acid/Ellagic Acid as Materials for Potential Medical Application.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 May 28; Vol. 25 (11). Date of Electronic Publication: 2024 May 28. - Publication Year :
- 2024
-
Abstract
- The aim of this work was to develop and characterize a thin films composed of hyaluronic acid/ellagic acid for potential medical application. Its principal novelty, distinct from the prior literature in terms of hyaluronic acid films supplemented with phenolic acids, resides in the predominant incorporation of ellagic acid-a distinguished compound-as the primary constituent of the films. Herein, ellagic acid was dissolved in two different solvents, i.e., acetic acid (AcOH) or sodium hydroxide (NaOH), and the surface properties of the resultant films were assessed using atomic force microscopy and contact angle measurements. Additionally, various physicochemical parameters were evaluated including moisture content, antioxidant activity, and release of ellagic acid in phosphate buffered saline. Furthermore, the evaluation of films' biocompatibility was conducted using human epidermal keratinocytes, dermal fibroblasts, and human amelanotic melanoma cells (A375 and G361), and the antimicrobial activity was elucidated accordingly against Staphylococcus aureus ATCC 6538 and Pseudomonas aeruginosa ATCC 15442. Our results showed that the films exhibited prominent antibacterial properties particularly against Staphylococcus aureus , with the 80HA/20EA/AcOH film indicating the strong biocidal activity against this strain leading to a significant reduction in viable cells. Comparatively, the 50HA/50EA/AcOH film also displayed biocidal activity against Staphylococcus aureus . This experimental approach could be a promising technique for future applications in regenerative dermatology or novel strategies in terms of bioengineering.
- Subjects :
- Humans
Pseudomonas aeruginosa drug effects
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Antioxidants pharmacology
Antioxidants chemistry
Fibroblasts drug effects
Keratinocytes drug effects
Microbial Sensitivity Tests
Cell Line, Tumor
Surface Properties
Hyaluronic Acid chemistry
Hyaluronic Acid pharmacology
Staphylococcus aureus drug effects
Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Ellagic Acid pharmacology
Ellagic Acid chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38892078
- Full Text :
- https://doi.org/10.3390/ijms25115891