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Downregulation of hsa-miR-100-5p May Be a Protective Factor in the Early Stages of Nephropathy in Type 1 Diabetes Mellitus.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 May 23; Vol. 25 (11). Date of Electronic Publication: 2024 May 23. - Publication Year :
- 2024
-
Abstract
- Type 1 Diabetes Mellitus (T1DM) can generate severe complications, such as Diabetic Kidney Disease (DKD) or Diabetic Nephropathy (DN), with it emerging as the leading cause of terminal (end-stage) renal disease all over the world. For T1DM, the clinical evaluation of DKD uses markers like the Glomerular Filtration Rate (GFR) and the Urinary Albumin Excretion (UAE). However, early diagnosis of DKD is still a challenge. For this reason, investigating molecular markers, such as microRNAs (miRNAs), offers a promising perspective to an early diagnosis, highlighting the stability and the ability to reflect incipient molecular manifestations. Thus, here we investigated four miRNAs (hsa-let-7i-5p, hsa-miR-143-3p, hsa-miR-501-3p, and hsa-miR-100-5p) regarding nephropathy in patients with T1DM, considering the albuminuria (micro and macro) as a standard to evaluate the groups. As a result, we found a reduced expression of miR-100-5p in patients with MIC, indicating a protective role in nephropathy. Beyond that, expression levels between the groups (Non vs. UAE) were not significant when comparing the miRNAs miR-501-3p and miR-143-3p. Finally, miR-143-3p and miR-100-5p were linked to some target genes such as AKT1, MMP13, and IGF1R, that are connected to signal pathways and cellular metabolism.
- Subjects :
- Adult
Female
Humans
Male
Middle Aged
Albuminuria genetics
Down-Regulation genetics
Glomerular Filtration Rate
Receptor, IGF Type 1 genetics
Receptor, IGF Type 1 metabolism
Biomarkers analysis
Diabetes Mellitus, Type 1 genetics
Diabetes Mellitus, Type 1 complications
Diabetic Nephropathies genetics
Diabetic Nephropathies metabolism
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38891851
- Full Text :
- https://doi.org/10.3390/ijms25115663