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Atroposelective catalysis.
- Source :
-
Nature reviews. Chemistry [Nat Rev Chem] 2024 Jul; Vol. 8 (7), pp. 497-517. Date of Electronic Publication: 2024 Jun 18. - Publication Year :
- 2024
-
Abstract
- Atropisomeric compounds-stereoisomers that arise from the restricted rotation about a single bond-have attracted widespread attention in recent years due to their immense potential for applications in a variety of fields, including medicinal chemistry, catalysis and molecular nanoscience. This increased interest led to the invention of new molecular motors, the incorporation of atropisomers into drug discovery programmes and a wide range of novel atroposelective reactions, including those that simultaneously control multiple stereogenic axes. A diverse set of synthetic methodologies, which can be grouped into desymmetrizations, (dynamic) kinetic resolutions, cross-coupling reactions and de novo ring formations, is available for the catalyst-controlled stereoselective synthesis of various atropisomer classes. In this Review, we generalize the concepts for the catalyst-controlled stereoselective synthesis of atropisomers within these categories with an emphasis on recent advancements and underdeveloped atropisomeric scaffolds beyond stereogenic C(sp <superscript>2</superscript> )-C(sp <superscript>2</superscript> ) axes. We also discuss more complex systems with multiple stereogenic axes or higher-order stereogenicity.<br /> (© 2024. Springer Nature Limited.)
Details
- Language :
- English
- ISSN :
- 2397-3358
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature reviews. Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38890539
- Full Text :
- https://doi.org/10.1038/s41570-024-00618-x