Back to Search
Start Over
Acute effects of acetylsalicylic acid on renal and hepatic function in normal humans.
- Source :
-
International journal of clinical pharmacology, therapy, and toxicology [Int J Clin Pharmacol Ther Toxicol] 1985 Mar; Vol. 23 (3), pp. 141-4. - Publication Year :
- 1985
-
Abstract
- The effect of a single oral dose (1 g) of acetylsalicylic acid (ASA) on renal function and hepatic enzymes as well as prothrombin time was studied in two series of experiments on normal human volunteers. Radioimmunoassay of albumin and beta 2-microglobulin excretion rates in urine revealed a statistically significant increase in both beta 2-microglobulin and albumin excretion rates within 2 h after dosage. Hepatic enzymes were not influenced by a single dose of ASA, while a statistically significant reduction in prothrombin time was registered. High-pressure liquid chromatography was used for measuring serum levels of ASA and salicylic acid (SA). Peak levels of 500 mumol/l and 150 mumol/l for SA and ASA, respectively, were found.
- Subjects :
- Adolescent
Adult
Alanine Transaminase blood
Albuminuria chemically induced
Aspartate Aminotransferases blood
Aspirin blood
Female
Humans
Liver enzymology
Male
Middle Aged
Proteinuria chemically induced
Prothrombin Time
Salicylates blood
Salicylic Acid
beta 2-Microglobulin urine
Aspirin pharmacology
Kidney drug effects
Liver drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0174-4879
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of clinical pharmacology, therapy, and toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 3888856