Back to Search
Start Over
Zingiber officinale promotes autophagy and apoptosis in human oral cancer through the C/EBP homologous protein.
- Source :
-
Cancer science [Cancer Sci] 2024 Aug; Vol. 115 (8), pp. 2701-2717. Date of Electronic Publication: 2024 Jun 18. - Publication Year :
- 2024
-
Abstract
- The rhizome of Zingiber officinale (Z. officinale), commonly known as ginger, has been characterized as a potential drug candidate due to its antitumor effects. However, the chemotherapeutic effect of ginger on human oral cancer remains poorly understood. In this study, we examined the effects of an ethanol extract of Z. officinale rhizomes (ZOE) on oral cancer and identified the components responsible for its pharmacological activity. ZOE exerts its inhibitory activity in oral cancer by inducing both autophagy and apoptosis simultaneously. Mechanistically, ZOE-induced autophagy and apoptosis in oral cancer are attributed to the reactive oxygen species (ROS)-mediated endoplasmic reticulum stress response. Additionally, we identified two active components of ZOE, 1-dehydro-6-gingerdione and 8-shogaol, which were sufficient to stimulate autophagy initiation and apoptosis induction by enhancing CHOP expression. These results suggest that ZOE and its two active components induce ROS generation, upregulate CHOP, initiate autophagy and apoptosis, and hold promising therapeutics against human oral cancer.<br /> (© 2024 The Author(s). Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.)
- Subjects :
- Humans
Cell Line, Tumor
Animals
Catechols pharmacology
Mice
Rhizome chemistry
Xenograft Model Antitumor Assays
Antineoplastic Agents, Phytogenic pharmacology
Zingiber officinale chemistry
Autophagy drug effects
Apoptosis drug effects
Transcription Factor CHOP metabolism
Mouth Neoplasms drug therapy
Mouth Neoplasms pathology
Mouth Neoplasms metabolism
Reactive Oxygen Species metabolism
Plant Extracts pharmacology
Endoplasmic Reticulum Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7006
- Volume :
- 115
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer science
- Publication Type :
- Academic Journal
- Accession number :
- 38888067
- Full Text :
- https://doi.org/10.1111/cas.16248