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CD28-CD57+ T cells from head and neck cancer patients produce high levels of cytotoxic granules and type II interferon but are not senescent.
- Source :
-
Oncoimmunology [Oncoimmunology] 2024 Jun 14; Vol. 13 (1), pp. 2367777. Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- T lymphocytes expressing CD57 and lacking costimulatory receptors CD27/CD28 have been reported to accumulate with aging, chronic infection, and cancer. These cells are described as senescent, with inability to proliferate but enhanced cytolytic and cytokine-producing capacity. However, robust functional studies on these cells taken directly from cancer patients are lacking. We isolated these T cells and their CD27/28+ counterparts from blood and tumor samples of 50 patients with previously untreated head and neck cancer. Functional studies confirmed that these cells have enhanced ability to degranulate and produce IFN-γ. They also retain the ability to proliferate, thus are not senescent. These data suggest that CD27/28-CD57+ CD8+ T cells are a subset of highly differentiated, CD45RA+ effector memory (T <subscript>EMRA</subscript> ) cells with retained proliferative capacity. Patients with > 34% of these cells among CD8+ T cells in the blood had a higher rate of locoregional disease relapse, suggesting these cells may have prognostic significance.<br />Competing Interests: NCS discloses consulting fees from Sensorion, Regeneron, and GeoVax in addition to research funding from Astex Pharmaceuticals. The authors have no conflicting financial interests related to this work.<br /> (© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Cell Proliferation
Cellular Senescence immunology
CD28 Antigens metabolism
CD57 Antigens metabolism
CD8-Positive T-Lymphocytes immunology
Head and Neck Neoplasms immunology
Head and Neck Neoplasms pathology
Interferon-gamma metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2162-402X
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Oncoimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 38887372
- Full Text :
- https://doi.org/10.1080/2162402X.2024.2367777