Rat strain differences in seizure frequency and hilar neuron loss after systemic treatment with pilocarpine.

Authors :: Junghans K
Wyeth M
Buckmaster PS
Source :: Epilepsy research [Epilepsy Res] 2024 Aug; Vol. 204, pp. 107384. Date of Electronic Publication: 2024 Jun 13.
Publication Year :: 2024
Abstract: At least 3 months after systemic treatment with pilocarpine to induce status epilepticus, Long-Evans and Sprague-Dawley rats were video-EEG monitored for seizures continuously for 1 month. Rats were then perfused, hippocampi were processed for Nissl staining, and hilar neurons were quantified. Seizure frequency in Long-Evans rats was 1/10th of that in Sprague-Dawley rats, and more variable. Hilar neuron loss was also less severe in Long-Evans rats. However, there was no correlation between hilar neuron loss and seizure frequency in either strain. The low and variable seizure frequency suggests limited usefulness of pilocarpine-treated Long-Evans rats for some epilepsy experiments.<br />Competing Interests: Declaration of Competing Interest None.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Subjects :: Animals
Rats
Male
Species Specificity
Hippocampus drug effects
Hippocampus pathology
Disease Models, Animal
Status Epilepticus chemically induced
Status Epilepticus pathology
Status Epilepticus drug therapy
Pilocarpine toxicity
Rats, Sprague-Dawley
Rats, Long-Evans
Seizures chemically induced
Seizures drug therapy
Seizures physiopathology
Neurons drug effects
Neurons pathology
Electroencephalography

Full Text Access

Tools