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11 C-methionine in the diagnostics and management of glioblastoma patients with rapid early progression: nonrandomized, open label, prospective clinical trial (GlioMET).
- Source :
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BMC cancer [BMC Cancer] 2024 Jun 15; Vol. 24 (1), pp. 736. Date of Electronic Publication: 2024 Jun 15. - Publication Year :
- 2024
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Abstract
- Background: Glioblastoma (GBM) is the most common and aggressive primary brain cancer. The treatment of GBM consists of a combination of surgery and subsequent oncological therapy, i.e., radiotherapy, chemotherapy, or their combination. If postoperative oncological therapy involves irradiation, magnetic resonance imaging (MRI) is used for radiotherapy treatment planning. Unfortunately, in some cases, a very early worsening (progression) or return (recurrence) of the disease is observed several weeks after the surgery and is called rapid early progression (REP). Radiotherapy planning is currently based on MRI for target volumes definitions in many radiotherapy facilities. However, patients with REP may benefit from targeting radiotherapy with other imaging modalities. The purpose of the presented clinical trial is to evaluate the utility of <superscript>11</superscript> C-methionine in optimizing radiotherapy for glioblastoma patients with REP.<br />Methods: This study is a nonrandomized, open-label, parallel-setting, prospective, monocentric clinical trial. The main aim of this study was to refine the diagnosis in patients with GBM with REP and to optimize subsequent radiotherapy planning. Glioblastoma patients who develop REP within approximately 6 weeks after surgery will undergo <superscript>11</superscript> C-methionine positron emission tomography (PET/CT) examinations. Target volumes for radiotherapy are defined using both standard planning T1-weighted contrast-enhanced MRI and PET/CT. The primary outcome is progression-free survival defined using RANO criteria and compared to a historical cohort with REP treated without PET/CT optimization of radiotherapy.<br />Discussion: PET is one of the most modern methods of molecular imaging. <superscript>11</superscript> C-Methionine is an example of a radiolabelled (carbon 11) amino acid commonly used in the diagnosis of brain tumors and in the evaluation of response to treatment. Optimized radiotherapy may also have the potential to cover those regions with a high risk of subsequent progression, which would not be identified using standard-of-care MRI for radiotherapy planning. This is one of the first study focused on radiotherapy optimization for subgroup of patinets with REP.<br />Trial Registration: NCT05608395, registered on 8.11.2022 in clinicaltrials.gov; EudraCT Number: 2020-000640-64, registered on 26.5.2020 in clinicaltrialsregister.eu. Protocol ID: MOU-2020-01, version 3.2, date 18.09.2020.<br /> (© 2024. The Author(s).)
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
Carbon Radioisotopes
Magnetic Resonance Imaging methods
Positron Emission Tomography Computed Tomography methods
Prospective Studies
Radiopharmaceuticals therapeutic use
Radiotherapy Planning, Computer-Assisted methods
Brain Neoplasms diagnostic imaging
Brain Neoplasms therapy
Brain Neoplasms radiotherapy
Brain Neoplasms diagnosis
Disease Progression
Glioblastoma diagnostic imaging
Glioblastoma therapy
Glioblastoma diagnosis
Glioblastoma radiotherapy
Methionine
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 38879476
- Full Text :
- https://doi.org/10.1186/s12885-024-12469-2