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Protocol for identifying and comparing molecular prognosis subtypes of IgAN using R.
- Source :
-
STAR protocols [STAR Protoc] 2024 Sep 20; Vol. 5 (3), pp. 103138. Date of Electronic Publication: 2024 Jun 15. - Publication Year :
- 2024
-
Abstract
- By providing a comprehensive view of protein dynamics, quantitative proteomics has emerged as a powerful tool for a better understanding of disease mechanisms. Here, we present a general workflow for identifying and comparing molecular subtypes of disease using proteomics data using R software. We describe steps for data preprocessing, feature selection, determination of subtypes, and functional interpretation of subtypes. These analyses can help us understand the nature of heterogeneous diseases, which is crucial for accurate diagnosis and personalized treatment. For complete details on the use and execution of this protocol, please refer to Chen et al. <superscript>1</superscript> .<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Prognosis
Computational Biology methods
Proteomics methods
Software
Subjects
Details
- Language :
- English
- ISSN :
- 2666-1667
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- STAR protocols
- Publication Type :
- Academic Journal
- Accession number :
- 38878284
- Full Text :
- https://doi.org/10.1016/j.xpro.2024.103138