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Is the strength of single HLA antigen mismatch variable in kidney transplant survival?
- Source :
-
Transplantation [Transplantation] 1979 Oct; Vol. 28 (4), pp. 313-5. - Publication Year :
- 1979
-
Abstract
- The survival rate among 458 cadaver kidney grafts with "full-house" four HLA-A,B antigens detected in the donor, three being identical to those of the recipient and only one mismatched, was studied specifically in relation to antigen incompatibility. At the A locus, the A3 incompatibility was associated with a lower transplant survival (44% at 2 years) than all of the others, and particularly more than the A11 (80% at 2 years) (P less than 0.003 but without significance after correction multiplying by the number of tested alleles). At the B locus, there was no significant difference in survival rate among the alleles. These results are only preliminary and need confirmation based on longer series permitting possible cross-reactions which exit between donor and recipient antigens to be taken into consideration.
Details
- Language :
- English
- ISSN :
- 0041-1337
- Volume :
- 28
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 388764
- Full Text :
- https://doi.org/10.1097/00007890-197910000-00009