Back to Search
Start Over
The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy.
- Source :
-
Immunology and cell biology [Immunol Cell Biol] 2024 Sep; Vol. 102 (8), pp. 721-733. Date of Electronic Publication: 2024 Jun 14. - Publication Year :
- 2024
-
Abstract
- Antibiotic resistance is a major public health threat, and alternatives to antibiotic therapy are urgently needed. Immunotherapy, particularly the blockade of inhibitory immune checkpoints, is a leading treatment option in cancer and autoimmunity. In this study, we used a murine model of Salmonella Typhimurium infection to investigate whether immune checkpoint blockade could be applied to bacterial infection. We found that the immune checkpoint T-cell immunoglobulin and ITIM domain (TIGIT) was significantly upregulated on lymphocytes during infection, particularly on CD4 <superscript>+</superscript> T cells, drastically limiting their proinflammatory function. Blockade of TIGIT in vivo using monoclonal antibodies was able to enhance immunity and improve bacterial clearance. The efficacy of anti-TIGIT was dependent on the capacity of the antibody to bind to Fc (fragment crystallizable) receptors, giving important insights into the mechanism of anti-TIGIT therapy. This research suggests that targeting immune checkpoints, such as TIGIT, has the potential to enhance immune responses toward bacteria and restore antibacterial treatment options in the face of antibiotic resistance.<br /> (© 2024 The Author(s). Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of the Australian and New Zealand Society for Immunology, Inc.)
- Subjects :
- Animals
Mice
Salmonella typhimurium immunology
T-Lymphocytes immunology
Immune Checkpoint Inhibitors pharmacology
Immune Checkpoint Inhibitors therapeutic use
Disease Models, Animal
Antibodies, Monoclonal pharmacology
Humans
Receptors, Immunologic metabolism
Immunotherapy methods
Mice, Inbred C57BL
Up-Regulation drug effects
Bacterial Infections immunology
Bacterial Infections therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1711
- Volume :
- 102
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Immunology and cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 38873699
- Full Text :
- https://doi.org/10.1111/imcb.12794