Back to Search
Start Over
Interreader and Intrareader Reproducibility of 18 F-Flotufolastat Image Interpretation in Patients with Newly Diagnosed or Recurrent Prostate Cancer: Data from Two Phase 3 Prospective Multicenter Studies.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2024 Aug 01; Vol. 65 (8), pp. 1239-1243. Date of Electronic Publication: 2024 Aug 01. - Publication Year :
- 2024
-
Abstract
- Interreader and intrareader reproducibility of <superscript>18</superscript> F-flotufolastat PET/CT scans in newly diagnosed and recurrent prostate cancer patients was assessed from masked image evaluations from two phase 3 studies. Methods: <superscript>18</superscript> F-flotufolastat PET/CT images of newly diagnosed ( n = 352) or recurrent ( n = 389) patients were evaluated by 3 masked readers. Cohen κ was used to assess pairwise patient- and region-level interreader agreement. Agreement among all readers was assessed using Fleiss κ. Intrareader agreement between the first and repeat read (20% of images, ≥4 wk later) was assessed using Cohen κ. Results: Pairwise interreader agreement was 95% or better (newly diagnosed) and 75% or better (recurrent). The κ coefficients were impacted by the high-agreement-low-κ paradox: Cohen κ ranged from not estimable to 0.55, whereas Fleiss κ was 0.50 (newly diagnosed) and 0.41 (recurrent). Agreement was highest in the prostate of newly diagnosed patients (≥95%) and in the pelvic lymph nodes in recurrent patients (≥87%). Intrareader agreement was 86% or better across both populations. Conclusion: <superscript>18</superscript> F-flotufolastat PET/CT images can be reliably interpreted, with a high degree of inter- and intrareader agreement.<br /> (© 2024 by the Society of Nuclear Medicine and Molecular Imaging.)
Details
- Language :
- English
- ISSN :
- 1535-5667
- Volume :
- 65
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38871390
- Full Text :
- https://doi.org/10.2967/jnumed.123.267306