Protective effects of growth hormone - releasing hormone antagonists in the lungs of septic mice.

Authors :: Fakir S
Kubra KT
Akhter MS
Uddin MA
Barabutis N
Source :: Cellular signalling [Cell Signal] 2024 Sep; Vol. 121, pp. 111260. Date of Electronic Publication: 2024 Jun 12.
Publication Year :: 2024
Abstract: Growth hormone-releasing hormone antagonists (GHRHAnt) have been associated with antitumor and antioxidative activities. The present study investigates for the first time the effects of those compounds towards pro-inflammatory cytokine expression in a murine model of cecal ligation and puncture (CLP) - induced sepsis. The results indicate that GHRHAnt JV-1-36 significantly suppressed IL-1α, IL-6, and pSTAT3 activation in septic lungs. Moreover, GHRHAnt treatment reduced bronchoalveolar lavage fluid (BALF) protein concentration, suggesting a protective effect of that compound in sepsis-induced lung edema. Based on those findings, it is suggested that GHRHAnt may represent an exciting new therapeutic possibility in sepsis-induced endotoxemia and lung injury.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interests.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Mice
Male
STAT3 Transcription Factor metabolism
Bronchoalveolar Lavage Fluid
Interleukin-6 metabolism
Disease Models, Animal
Sepsis drug therapy
Growth Hormone-Releasing Hormone antagonists & inhibitors
Growth Hormone-Releasing Hormone metabolism
Lung pathology
Lung metabolism
Lung drug effects

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