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Metagenomic next-generation sequencing reveals co-infection with Legionella pneumophila and Fusobacterium necrophorum in a patient with severe pneumonia: a case report.
- Source :
-
BMC pulmonary medicine [BMC Pulm Med] 2024 Jun 12; Vol. 24 (1), pp. 279. Date of Electronic Publication: 2024 Jun 12. - Publication Year :
- 2024
-
Abstract
- Background: Legionella pneumonia is one of the most severe types of atypical pneumonia, impairing multiple organ systems, posing a threat to life. Diagnosing Legionella pneumonia is challenging due to difficulties in culturing the bacteria and limitations in immunoassay sensitivity and specificity.<br />Case Presentation: This paper reports a rare case of sepsis caused by combined infection with Legionella pneumophila and Fusobacterium necrophorum, leading to respiratory failure, acute kidney injury, acute liver injury, myocardial damage, and electrolyte disorders. In addition, we systematically reviewed literature on patients with combined Legionella infections, analyzing their clinical features, laboratory results and diagnosis.<br />Conclusions: For pathogens that require prolonged incubation periods and are less sensitive to conventional culturing methods, metagenomic next-generation sequencing (mNGS) can be a powerful supplement to pathogen screening and plays a significant role in the auxiliary diagnosis of complex infectious diseases.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Metagenomics methods
Male
Middle Aged
Pneumonia, Bacterial microbiology
Pneumonia, Bacterial diagnosis
High-Throughput Nucleotide Sequencing
Legionella pneumophila genetics
Legionella pneumophila isolation & purification
Legionnaires' Disease diagnosis
Legionnaires' Disease microbiology
Fusobacterium Infections diagnosis
Fusobacterium Infections microbiology
Fusobacterium Infections complications
Fusobacterium necrophorum isolation & purification
Fusobacterium necrophorum genetics
Coinfection diagnosis
Coinfection microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2466
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC pulmonary medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38867173
- Full Text :
- https://doi.org/10.1186/s12890-024-03097-4