Back to Search Start Over

Sex-dependent regulation of vertebrate somatic growth and aging by germ cells.

Sex-dependent regulation of vertebrate somatic growth and aging by germ cells.

Authors :
Abe K
Ino H
Niwa T
Semmy D
Takaochi A
Nishimura T
Mogi C
Uenaka M
Ishii M
Tanaka K
Ohkawa Y
Ishitani T
Source :
Science advances [Sci Adv] 2024 Jun 14; Vol. 10 (24), pp. eadi1621. Date of Electronic Publication: 2024 Jun 12.
Publication Year :
2024

Abstract

The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri . In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.

Details

Language :
English
ISSN :
2375-2548
Volume :
10
Issue :
24
Database :
MEDLINE
Journal :
Science advances
Publication Type :
Academic Journal
Accession number :
38865462
Full Text :
https://doi.org/10.1126/sciadv.adi1621