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Controllable Regioselective [3+2] Cyclizations of N -CF 3 Imidoyl Chlorides and Ph 3 PNNC: Divergent Synthesis of N -CF 3 Triazoles.

Authors :
Gao YF
Zhang RZ
Xu C
Wang M
Source :
Organic letters [Org Lett] 2024 Jun 21; Vol. 26 (24), pp. 5087-5091. Date of Electronic Publication: 2024 Jun 12.
Publication Year :
2024

Abstract

Presented herein are two distinct regiodivergent [3+2] cyclization reactions between N -CF <subscript>3</subscript> imidoyl chlorides and N -isocyaniminotriphenylphosphorane (NIITP) that include flexible modulation of the electronic properties of NIITP. The regioselectivity of reactions was different in the absence and presence of the Mo catalyst. The approach provides alternative efficient and scalable routes for N -CF <subscript>3</subscript> triazole synthesis, demonstrating a broad substrate scope, excellent functional group tolerance, and practical advantages.

Details

Language :
English
ISSN :
1523-7052
Volume :
26
Issue :
24
Database :
MEDLINE
Journal :
Organic letters
Publication Type :
Academic Journal
Accession number :
38864522
Full Text :
https://doi.org/10.1021/acs.orglett.4c01275