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[Study on Circulating Tumor Cell Detection System Based on Microfluidic Chip].

Authors :
Di Y
Luo J
Gao D
Yang H
Source :
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation [Zhongguo Yi Liao Qi Xie Za Zhi] 2024 May 30; Vol. 48 (3), pp. 277-280.
Publication Year :
2024

Abstract

Objective: To achieve high throughput and high detection rate of circulating tumor cells (CTCs) in human peripheral blood, and to provide efficient and accurate early screening for cancer patients.<br />Methods: A microfluidic chip with the integration of sorting, enrichment and detection was designed, and CTCs at the single cell level were detected by fluorescence detection system to obtain the number of CTCs in samples.<br />Results: The peripheral blood samples after lysed red blood cells were used for 6 experiments. When the injection rate reached 0.2 mL/h, CTCs could reach the best detection rate of 78.6%, and the correlation coefficient within the group was above 0.8.<br />Conclusion: CTCs detection system can achieve high detection rate and has good reliability, which can provide a reliable reference for clinical research in related fields.

Details

Language :
Chinese
ISSN :
1671-7104
Volume :
48
Issue :
3
Database :
MEDLINE
Journal :
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation
Publication Type :
Academic Journal
Accession number :
38863093
Full Text :
https://doi.org/10.12455/j.issn.1671-7104.230595