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Multifunctional Metal-Organic Frameworks Driven Three-Dimensional Folded Paper-Based Microfluidic Analysis Device for Chlorpyrifos Detection.

Authors :
Liu S
Zhang M
Chen Q
Ouyang Q
Source :
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jun 26; Vol. 72 (25), pp. 14375-14385. Date of Electronic Publication: 2024 Jun 11.
Publication Year :
2024

Abstract

Chlorpyrifos (CPF) residues in food pose a serious threat to ecosystems and human health. Herein, we propose a three-dimensional folded paper-based microfluidic analysis device (3D-μPAD) based on multifunctional metal-organic frameworks, which can achieve rapid quantitative detection of CPF by fluorescence-colorimetric dual-mode readout. Upconversion nanomaterials were first coupled with a bimetal organic framework possessing peroxidase activity to create a fluorescence-quenched nanoprobe. After that, the 3D-μPAD was finished by loading the nanoprobe onto the paper-based detection zone and spraying it with a color-developing solution. With CPF present, the fluorescence intensity of the detection zone gradually recovers, the color changes from colorless to blue. This showed a good linear relationship with the concentration of CPF, and the limits of detection were 0.028 (fluorescence) and 0.043 (colorimetric) ng/mL, respectively. Moreover, the 3D-μPAD was well applied in detecting real samples with no significant difference compared with the high-performance liquid chromatography method. We believe it has huge potential for application in the on-site detection of food hazardous substance residues.

Details

Language :
English
ISSN :
1520-5118
Volume :
72
Issue :
25
Database :
MEDLINE
Journal :
Journal of agricultural and food chemistry
Publication Type :
Academic Journal
Accession number :
38860923
Full Text :
https://doi.org/10.1021/acs.jafc.4c02875