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Multifunctional Metal-Organic Frameworks Driven Three-Dimensional Folded Paper-Based Microfluidic Analysis Device for Chlorpyrifos Detection.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jun 26; Vol. 72 (25), pp. 14375-14385. Date of Electronic Publication: 2024 Jun 11. - Publication Year :
- 2024
-
Abstract
- Chlorpyrifos (CPF) residues in food pose a serious threat to ecosystems and human health. Herein, we propose a three-dimensional folded paper-based microfluidic analysis device (3D-μPAD) based on multifunctional metal-organic frameworks, which can achieve rapid quantitative detection of CPF by fluorescence-colorimetric dual-mode readout. Upconversion nanomaterials were first coupled with a bimetal organic framework possessing peroxidase activity to create a fluorescence-quenched nanoprobe. After that, the 3D-μPAD was finished by loading the nanoprobe onto the paper-based detection zone and spraying it with a color-developing solution. With CPF present, the fluorescence intensity of the detection zone gradually recovers, the color changes from colorless to blue. This showed a good linear relationship with the concentration of CPF, and the limits of detection were 0.028 (fluorescence) and 0.043 (colorimetric) ng/mL, respectively. Moreover, the 3D-μPAD was well applied in detecting real samples with no significant difference compared with the high-performance liquid chromatography method. We believe it has huge potential for application in the on-site detection of food hazardous substance residues.
- Subjects :
- Colorimetry methods
Colorimetry instrumentation
Limit of Detection
Pesticide Residues analysis
Pesticide Residues chemistry
Insecticides analysis
Insecticides chemistry
Microfluidic Analytical Techniques instrumentation
Lab-On-A-Chip Devices
Chlorpyrifos analysis
Metal-Organic Frameworks chemistry
Paper
Food Contamination analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 72
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38860923
- Full Text :
- https://doi.org/10.1021/acs.jafc.4c02875