Back to Search Start Over

Scoping review of clinical decision support systems for multiple sclerosis management: Leveraging information technology and massive health data.

Authors :
Demuth S
Ed-Driouch C
Dumas C
Laplaud D
Edan G
Vince N
De Sèze J
Gourraud PA
Source :
European journal of neurology [Eur J Neurol] 2025 Jan; Vol. 32 (1), pp. e16363. Date of Electronic Publication: 2024 Jun 11.
Publication Year :
2025

Abstract

Background and Purpose: Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system, with numerous therapeutic options, but a lack of biomarkers to support a mechanistic approach to precision medicine. A computational approach to precision medicine could proceed from clinical decision support systems (CDSSs). They are digital tools aiming to empower physicians through the clinical applications of information technology and massive data. However, the process of their clinical development is still maturing; we aimed to review it in the field of MS.<br />Methods: For this scoping review, we screened systematically the PubMed database. We identified 24 articles reporting 14 CDSS projects and compared their technical and software development aspects.<br />Results: The projects position themselves in various contexts of usage with various algorithmic approaches: expert systems, CDSSs based on similar patients' data visualization, and model-based CDSSs implementing mathematical predictive models. So far, no project has completed its clinical development up to certification for clinical use with global release. Some CDSSs have been replaced at subsequent project iterations. The most advanced projects did not necessarily report every step of clinical development in a dedicated article (proof of concept, offline validation, refined prototype, live clinical evaluation, comparative prospective evaluation). They seek different software distribution options to integrate into health care: internal usage, "peer-to-peer," and marketing distribution.<br />Conclusions: This review illustrates the potential of clinical applications of information technology and massive data to support MS management and helps clarify the roadmap for future projects as a multidisciplinary and multistep process.<br /> (© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)

Details

Language :
English
ISSN :
1468-1331
Volume :
32
Issue :
1
Database :
MEDLINE
Journal :
European journal of neurology
Publication Type :
Academic Journal
Accession number :
38860844
Full Text :
https://doi.org/10.1111/ene.16363