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Optical coherence tomography angiography reveals macular microvascular changes in myopic adolescents following orthokeratology lens wear.
- Source :
-
European journal of ophthalmology [Eur J Ophthalmol] 2024 Sep; Vol. 34 (5), pp. 1299-1307. Date of Electronic Publication: 2024 Jun 11. - Publication Year :
- 2024
-
Abstract
- Background: This study aimed to investigate the 6-month effects of wearing orthokeratology (OK) lenses on the retina vessel density (VD), vessel diameter index (VDI), and foveal avascular zone (FAZ) of myopia children using optical coherence tomography angiography, and to further investigate the underlying mechanisms of Orthokeratology in myopia control.<br />Methods: Sixty-two eyes form 62 subjects were included in the study. Baseline and 6-month measurements of axial length (AL), anterior chamber depth (ACD), FAZ area, FAZ perimeter, FAZ circularity, vessel density (VD) and VDI from both the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were obtained.<br />Results: The mean age of the participants was 11.02 years (range: 8 years to 15 years), with 41.9% males and 58.1% females. Six months after orthokeratology, ACD decreased significantly, and AL remain unchanged. SCP-VD and DCP-VD significantly increased after treatment without obvious change of VDI, and FAZ parameters remained unchanged. During follow-up period, SCP-VD increased in all subgroups especially in mild myopia group, and DCP-VD increased significantly in all subgroups except for the group 8-10 years.<br />Conclusion: After the 6-month treatment of orthokeratology in myopia children, the macular microvasculature changed significantly. We observed a significant increase of vessel densities in both SCP and DCP without obvious effect on vascular morphology. The changes of DCP-VD tended to be more sensitive in the elder subgroup, and the efficacy of orthokeratology might be greater in mild myopia group. OCT-A may provide additional information on myopia progression and the mechanisms of controlling myopia with OK lens treatment.<br />Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Humans
Adolescent
Female
Male
Child
Macula Lutea blood supply
Macula Lutea diagnostic imaging
Follow-Up Studies
Refraction, Ocular physiology
Axial Length, Eye
Fundus Oculi
Visual Acuity physiology
Contact Lenses
Tomography, Optical Coherence methods
Orthokeratologic Procedures
Retinal Vessels diagnostic imaging
Retinal Vessels physiopathology
Myopia physiopathology
Myopia therapy
Fluorescein Angiography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1724-6016
- Volume :
- 34
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 38859764
- Full Text :
- https://doi.org/10.1177/11206721241260456