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Skeletal-Related Events in Patients With Multiple Myeloma: A Comprehensive Retrospective Cohort Study.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2024 Jun 10; Vol. 39 (22), pp. e175. Date of Electronic Publication: 2024 Jun 10. - Publication Year :
- 2024
-
Abstract
- Background: Multiple myeloma (MM) patients are at risk of skeletal-related events (SREs) like spinal cord compression, pathologic fractures, bone surgery, and radiation to bone. Real-world data regarding SREs in MM are limited.<br />Methods: We conducted a large, retrospective, nationwide cohort study using the Korean Health Insurance Review and Assessment Service (HIRA) database from 2007 to 2018.<br />Results: Over a 12-year study period, we identified 6,717 patients who developed symptomatic MM. After a median follow-up of 35.1 months (interquartile range [IQR], 20.8-58.2 months), 43.6% of these patients experienced SREs, and 39.6% had four or more SREs. One in five patients (20.0%) experienced pathologic fractures within the first year of follow-up. The median time to first SRE was 9.6 months (IQR, 1.2-25.8 months), with 3.0 months in the group with prior SREs and 19.8 months in the group without prior SREs. During follow-up, 78.5% of patients received bisphosphonates. Multiple logistic regression analysis revealed several factors associated with an increased risk of SREs, including being female (odds ratio [OR], 1.44), aged 50 or older (OR, 1.87), having cerebrovascular disease (OR, 1.34), undergoing first-line chemotherapy regimens not containing bortezomib or lenalidomide (OR, 1.49), and being in the group with prior SREs and bisphosphonate use (OR, 5.63), compared to the group without prior SREs and without bisphosphonate use.<br />Conclusion: This population-based study is the first to report the incidence and risk factors of SREs in Korean MM patients, which can be used to assess their bone health.<br />Competing Interests: The authors have no potential conflicts of interest to disclose.<br /> (© 2024 The Korean Academy of Medical Sciences.)
- Subjects :
- Humans
Female
Male
Retrospective Studies
Middle Aged
Aged
Diphosphonates therapeutic use
Risk Factors
Databases, Factual
Republic of Korea epidemiology
Bone Density Conservation Agents therapeutic use
Odds Ratio
Fractures, Spontaneous etiology
Fractures, Spontaneous epidemiology
Spinal Cord Compression etiology
Adult
Logistic Models
Multiple Myeloma epidemiology
Multiple Myeloma pathology
Multiple Myeloma diagnosis
Multiple Myeloma complications
Subjects
Details
- Language :
- English
- ISSN :
- 1598-6357
- Volume :
- 39
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 38859738
- Full Text :
- https://doi.org/10.3346/jkms.2024.39.e175