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Enantioselective β-Selective Addition of Isoxazolidin-5-ones to Allenoates Catalyzed by Quaternary Ammonium Salts.
- Source :
-
Synthesis [Synthesis (Stuttg)] 2023 Jun; Vol. 55 (11), pp. 1706-1713. Date of Electronic Publication: 2022 Oct 27. - Publication Year :
- 2023
-
Abstract
- The enantioselective addition of isoxazolidin-5-ones to the β-carbon of allenoates has been carried out by using a novel spirobiindane-based quaternary ammonium salt catalyst. This protocol, which proceeds under classical liquid-solid phase-transfer conditions, gives access to unprecedented highly functionalized β <superscript>2,2</superscript> -amino acid derivatives with good enantioselectivities and in high yields, and further manipulations of these products have been carried out as well.<br />Competing Interests: Conflict of Interest The authors declare no conflict of interest.
Details
- Language :
- English
- ISSN :
- 0039-7881
- Volume :
- 55
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 38855403
- Full Text :
- https://doi.org/10.1055/a-1948-5493