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Continuous Flow Electroselenocyclization of Allylamides and Unsaturated Oximes to Selenofunctionalized Oxazolines and Isoxazolines.

Continuous Flow Electroselenocyclization of Allylamides and Unsaturated Oximes to Selenofunctionalized Oxazolines and Isoxazolines.

Authors :
Alzaidi O
Wirth T
Source :
ACS organic & inorganic Au [ACS Org Inorg Au] 2024 Mar 11; Vol. 4 (3), pp. 350-355. Date of Electronic Publication: 2024 Mar 11 (Print Publication: 2024).
Publication Year :
2024

Abstract

The synthesis of selenofunctionalized oxazolines and isoxazolines from N -allyl benzamides and unsaturated oximes with diselenides was studied by utilizing a continuous flow electrochemical approach. At mild reaction conditions and short reaction times of 10 min product yields of up to 90% were achieved including a scale-up reaction. A broad substrate scope was studied and the reaction was shown to have a wide functional group tolerance.<br />Competing Interests: The authors declare no competing financial interest.<br /> (© 2024 The Authors. Published by American Chemical Society.)

Details

Language :
English
ISSN :
2694-247X
Volume :
4
Issue :
3
Database :
MEDLINE
Journal :
ACS organic & inorganic Au
Publication Type :
Academic Journal
Accession number :
38855333
Full Text :
https://doi.org/10.1021/acsorginorgau.4c00008