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Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer's dementia.
- Source :
-
Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2024 Jul 29; Vol. 379 (1906), pp. 20230233. Date of Electronic Publication: 2024 Jun 10. - Publication Year :
- 2024
-
Abstract
- Long-term potentiation (LTP)-like activity can be induced by stimulation protocols such as paired associative stimulation (PAS). We aimed to determine whether PAS-induced LTP-like activity (PAS-LTP) of the dorsolateral prefrontal cortex (DLPFC) is associated with cortical thickness and other structural measures impaired in Alzheimer's dementia (AD). We also explored longitudinal relationships between these brain structures and PAS-LTP response after a repetitive PAS (rPAS) intervention. Mediation and regression analyses were conducted using data from randomized controlled trials with AD and healthy control participants. PAS-electroencephalography assessed DLPFC PAS-LTP. DLPFC thickness and surface area were acquired from T1-weighted magnetic resonance imaging. Fractional anisotropy and mean diffusivity (MD) of the superior longitudinal fasciculus (SLF)-a tract important to induce PAS-LTP-were measured with diffusion-weighted imaging. AD participants exhibited reduced DLPFC thickness and increased SLF MD. There was also some evidence that reduction in DLPFC thickness mediates DLPFC PAS-LTP impairment. Longitudinal analyses showed preliminary evidence that SLF MD, and to a lesser extent DLPFC thickness, is associated with DLPFC PAS-LTP response to active rPAS. This study expands our understanding of the relationships between brain structural changes and neuroplasticity. It provides promising evidence for a structural predictor to improving neuroplasticity in AD with neurostimulation. This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'.
- Subjects :
- Humans
Male
Aged
Female
Aged, 80 and over
Middle Aged
Electroencephalography
Magnetic Resonance Imaging
Prefrontal Cortex physiopathology
Prefrontal Cortex diagnostic imaging
Prefrontal Cortex physiology
Alzheimer Disease physiopathology
Dorsolateral Prefrontal Cortex diagnostic imaging
Dorsolateral Prefrontal Cortex physiopathology
Long-Term Potentiation
Neuronal Plasticity
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2970
- Volume :
- 379
- Issue :
- 1906
- Database :
- MEDLINE
- Journal :
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38853564
- Full Text :
- https://doi.org/10.1098/rstb.2023.0233