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Effect of the number of passes on diagnostic performance of EUS fine-needle biopsy of solid pancreatic masses: a systematic review and meta-analysis.
- Source :
-
Gastrointestinal endoscopy [Gastrointest Endosc] 2024 Oct; Vol. 100 (4), pp. 595-604.e8. Date of Electronic Publication: 2024 Jun 07. - Publication Year :
- 2024
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Abstract
- Background and Aims: The optimal number of passes to maximize the diagnostic ability of EUS fine-needle biopsy (FNB) of solid pancreatic masses (SPMs) is not well known. We conducted a systematic review to evaluate the impact of the incremental number of passes on diagnostic accuracy, tissue adequacy, and diagnostic yield for EUS-FNB of SPMs.<br />Methods: We searched MEDLINE, Embase, Scopus, and Cochrane Central for randomized controlled trials comparing per-pass diagnostic outcomes of FNB needles in patients with SPMs. Meta-analysis was conducted using random-effects models. A separate analysis was performed on studies that used contemporary Franseen and fork-tip needles.<br />Results: Overall, 19 randomized controlled trials (N = 3552) were identified. For EUS-FNB of SPMs, 3 passes with any FNB needle outperformed 2 passes for accuracy (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.20-2.09; I <superscript>2</superscript>  = 0%), adequacy (OR, 1.97; 95% CI, 1.30-2.83; I <superscript>2</superscript>  = 61%), and yield (OR, 2.12; 95% CI, 1.37-3.27; I <superscript>2</superscript>  = 14%). Adding a fourth or fifth pass resulted in no significant improvement in diagnostic parameters. When using contemporary FNB needles, adding a second to a single pass significantly improved accuracy (OR, 1.80; 95% CI, 1.23-2.63; I <superscript>2</superscript>  = 0%), adequacy (OR, 2.19; 95% CI, 1.65-2.90; I <superscript>2</superscript>  = 0%), and yield (OR, 2.72; 95% CI, 1.50-4.95; I <superscript>2</superscript>  = 0%). Adding a third pass to a second pass with contemporary needles improved adequacy (OR, 2.96; 95% CI, 1.97-4.46; I <superscript>2</superscript>  = 0%) but did not provide better diagnostic accuracy or yield.<br />Conclusions: Two passes with Franseen or fork-tip needles and 3 passes with any FNB needle suffice to provide optimal diagnostic performance for EUS-FNB of SPMs, without additional diagnostic benefits with more passes. Our results can inform future guidelines and quality benchmarks.<br />Competing Interests: Disclosure The following author disclosed financial relationships: S. Wani: Consultant for Enterotracker, Exact Sciences, and Lucid; research support from CDx Diagnostics, Exact Sciences, and Lucid. All other authors disclosed no financial relationships.<br /> (Copyright © 2024 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-6779
- Volume :
- 100
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Gastrointestinal endoscopy
- Publication Type :
- Academic Journal
- Accession number :
- 38852683
- Full Text :
- https://doi.org/10.1016/j.gie.2024.05.022