Back to Search
Start Over
Longitudinal Analysis of Brain Function-Structure Dependencies in 22q11.2 Deletion Syndrome and Psychotic Symptoms.
- Source :
-
Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2024 Sep; Vol. 9 (9), pp. 882-895. Date of Electronic Publication: 2024 Jun 05. - Publication Year :
- 2024
-
Abstract
- Background: Compared with conventional unimodal analysis, understanding how brain function and structure relate to one another opens a new biologically relevant assessment of neural mechanisms. However, how function-structure dependencies (FSDs) evolve throughout typical and abnormal neurodevelopment remains elusive. The 22q11.2 deletion syndrome (22q11.2DS) offers an important opportunity to study the development of FSDs and their specific association with the pathophysiology of psychosis.<br />Methods: Previously, we used graph signal processing to combine brain activity and structural connectivity measures in adults, quantifying FSD. Here, we combined FSD with longitudinal multivariate partial least squares correlation to evaluate FSD alterations across groups and among patients with and without mild to moderate positive psychotic symptoms. We assessed 391 longitudinally repeated resting-state functional and diffusion-weighted magnetic resonance images from 194 healthy control participants and 197 deletion carriers (ages 7-34 years, data collected over a span of 12 years).<br />Results: Compared with control participants, patients with 22q11.2DS showed a persistent developmental offset from childhood, with regions of hyper- and hypocoupling across the brain. Additionally, a second deviating developmental pattern showed an exacerbation during adolescence, presenting hypocoupling in the frontal and cingulate cortices and hypercoupling in temporal regions for patients with 22q11.2DS. Interestingly, the observed aggravation during adolescence was strongly driven by the group with positive psychotic symptoms.<br />Conclusions: These results confirm a central role of altered FSD maturation in the emergence of psychotic symptoms in 22q11.2DS during adolescence. The FSD deviations precede the onset of psychotic episodes and thus offer a potential early indication for behavioral interventions in individuals at risk.<br /> (Copyright © 2024 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Male
Adult
Female
Adolescent
Young Adult
Longitudinal Studies
Child
Diffusion Magnetic Resonance Imaging
DiGeorge Syndrome physiopathology
DiGeorge Syndrome complications
DiGeorge Syndrome pathology
Psychotic Disorders physiopathology
Psychotic Disorders diagnostic imaging
Brain physiopathology
Brain diagnostic imaging
Magnetic Resonance Imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2451-9030
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biological psychiatry. Cognitive neuroscience and neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 38849032
- Full Text :
- https://doi.org/10.1016/j.bpsc.2024.05.008