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Function of Steroid Receptor Coactivators in T Cells and Cancers: Implications for Cancer Immunotherapy.
- Source :
-
Critical reviews in immunology [Crit Rev Immunol] 2024; Vol. 44 (6), pp. 111-126. - Publication Year :
- 2024
-
Abstract
- Steroid receptor coactivator (SRC) family members (SRC1, SRC2 and SRC3) are transcriptional co-regulators. SRCs orchestrate gene transcription by inducing transactivation of nuclear receptors and other transcription factors. Overexpression of SRCs is widely implicated in a range of cancers, especially hormone-related cancers. As coactivators, SRCs regulate multiple metabolic pathways involved in tumor growth, invasion, metastasis, and chemo-resistance. Emerging evidence in recent years suggest that SRCs also regulate maturation, differentiation, and cytotoxicity of T cells by controlling metabolic activities. In this review, we summarize the current understanding of the function of SRCs in T cells as well as cancer cells. Importantly, the controversies of targeting SRCs for cancer immunotherapy as well as possible reconciliation strategies are also discussed.
Details
- Language :
- English
- ISSN :
- 1040-8401
- Volume :
- 44
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Critical reviews in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 38848298
- Full Text :
- https://doi.org/10.1615/CritRevImmunol.2024051613