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Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health.

Authors :
Diab R
Dimachkie L
Zein O
Dakroub A
Eid AH
Source :
Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Sep; Vol. 82 (3), pp. 1583-1597. Date of Electronic Publication: 2024 Jun 07.
Publication Year :
2024

Abstract

Obesity is a leading cause of morbidity and mortality globally. While the prevalence of obesity has been increasing, the incidence of its related complications including dyslipidemia and cardiovascular disease (CVD) has also been rising. Recent research has focused on modalities aimed at reducing obesity. Several modalities have been suggested including behavioral and dietary changes, medications, and bariatric surgery. These modalities differ in their effectiveness and invasiveness, with dietary changes gaining more interest due to their minimal risks compared to other modalities. Specifically, intermittent fasting (IF) has been gaining interest in the past decade. IF is characterized by cycles of alternating fasting and eating windows, with several different forms practiced. IF has been shown to reduce weight and alleviate obesity-related complications. Our review of clinical and experimental studies explores the effects of IF on the lipid profile, white adipose tissue (WAT) dynamics, and the gut microbiome. Notably, IF corrects dyslipidemia, reduces WAT accumulation, and decreases inflammation, which reduces CVD and obesity. This comprehensive analysis details the protective metabolic role of IF, advocating for its integration into public health practices.<br /> (© 2024. The Author(s).)

Details

Language :
English
ISSN :
1559-0283
Volume :
82
Issue :
3
Database :
MEDLINE
Journal :
Cell biochemistry and biophysics
Publication Type :
Academic Journal
Accession number :
38847940
Full Text :
https://doi.org/10.1007/s12013-024-01314-9