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Carrier-Free Self-Assembled Nanomedicines for Promoting Apoptosis and Inhibiting Proliferation in Hepatocellular Carcinoma.
- Source :
-
ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2024 Jul 08; Vol. 10 (7), pp. 4347-4358. Date of Electronic Publication: 2024 Jun 06. - Publication Year :
- 2024
-
Abstract
- In order to improve the effectiveness of tumor treatment and reduce the toxic side effects of drugs, we formed carrier-free multifunctional nanoparticles (BI NPs) by noncovalent interaction of berberine hydrochloride and IR780. BI NPs possessed the synergistic effects of promoting apoptosis, inhibiting proliferation and metastasis of tumors, and phototherapeutic treatment. Dispersive and passive targeting ability retention (EPR) effects of BI NPs on tumor sites in vivo could be monitored by fluorescence imaging. In addition, BI NPs exhibited effective reactive oxygen species (ROS) generation and photothermal conversion capabilities, photodynamic therapy (PDT), and photothermal therapy (PTT). Importantly, BI NPs inhibit tumor suppression through the AMPK/PI3K/AKT signaling pathway to inhibit tumor proliferation and metastasis. BI NPs not only have efficient in vivo multimodal therapeutic effects but also have good biosafety and potential clinical applications.
- Subjects :
- Humans
Animals
Mice
Reactive Oxygen Species metabolism
Photochemotherapy methods
Berberine pharmacology
Berberine chemistry
Berberine therapeutic use
Photothermal Therapy
Mice, Inbred BALB C
Cell Line, Tumor
Antineoplastic Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Apoptosis drug effects
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular pathology
Liver Neoplasms drug therapy
Liver Neoplasms pathology
Cell Proliferation drug effects
Nanoparticles chemistry
Nanoparticles therapeutic use
Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 2373-9878
- Volume :
- 10
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- ACS biomaterials science & engineering
- Publication Type :
- Academic Journal
- Accession number :
- 38841860
- Full Text :
- https://doi.org/10.1021/acsbiomaterials.4c00390