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Manganese(II) promotes prebiotically plausible non-enzymatic RNA ligation reactions.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Jun 20; Vol. 60 (51), pp. 6528-6531. Date of Electronic Publication: 2024 Jun 20. - Publication Year :
- 2024
-
Abstract
- Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5'-AMP as an analogue.
- Subjects :
- Prebiotics
Manganese chemistry
RNA chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 60
- Issue :
- 51
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 38836405
- Full Text :
- https://doi.org/10.1039/d4cc01086h