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Non-invasive prenatal testing: when results suggests maternal cancer.
- Source :
-
Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V [Med Genet] 2023 Dec 05; Vol. 35 (4), pp. 285-295. Date of Electronic Publication: 2023 Dec 05 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- It is now well-established that non-invasive prenatal testing (NIPT), originally designed to screen cell-free DNA (cfDNA) in maternal blood for the presence of common fetal trisomies, can lead to incidental detection of occult maternal malignancies. Retrospective evaluations have demonstrated that the detection of multiple copy number alterations in cfDNA is particularly suggestive of an incipient tumor and that cancer detection rates not only depend on tumor biology but also on applied NIPT technologies and downstream diagnostic investigations. Since the identification of a maternal cancer in pregnancy has implications for both woman and the unborn child, prospective studies are needed to provide evidence on best clinical practices and on clinical utility in terms of patient outcomes.<br />Competing Interests: Competing interests: The authors declare no conflict of interest.<br /> (© 2023 bei den Autoren, publiziert von De Gruyter.)
Details
- Language :
- English
- ISSN :
- 1863-5490
- Volume :
- 35
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V
- Publication Type :
- Academic Journal
- Accession number :
- 38835737
- Full Text :
- https://doi.org/10.1515/medgen-2023-2055