Mechanical Preload Reduction: Harnessing a Cornerstone of Heart Failure Management to Improve Clinical Outcomes.

Decongestion is a cornerstone therapeutic goal for those presenting with decompensated heart failure. Current approaches to clinical decongestion include reducing cardiac preload, which is typically limited to diuretics and hemofiltration. Several new technologies designed to mechanically reduce cardiac preload are in development. In this review, we discuss the pathophysiology of decompensated heart failure; the central role of targeting cardiac preload; emerging mechanical preload reduction technologies; and potential application of these devices.
Competing Interests: Disclosure: N.K.K. has received consulting honoraria and institutional grant support from Abbott Laboratories, Abiomed Inc., Boston Scientific, Medtronic, LivaNova, Getinge, and Zoll. M.K.K. has served on the advisory board for Abiomed Inc., Abbott Laboratories, and CorWave. D.B. has received an unrestricted, educational grant from Abiomed Inc. A.B. is a consultant to Abiomed Inc. The other authors have no conflicts of interest to report.
(Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO.)