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A kinase-dead natural polymorphism in the canine Tnni3k gene.
A kinase-dead natural polymorphism in the canine Tnni3k gene.
- Source :
-
MicroPublication biology [MicroPubl Biol] 2024 May 16; Vol. 2024. Date of Electronic Publication: 2024 May 16 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Most mammalian cardiomyocytes become polyploid in the neonatal period, concurrent with their loss of proliferative capacity. In mice, natural or engineered mutation of the cardiomyocyte-specific kinase gene Tnni3k causes a higher level of diploid CMs and a higher capacity to support proliferation after adult injury. Here, we identified a polymorphism in the canine Tnni3k gene that is particularly common in the West Highland White Terrier breed, and show that this variant eliminates Tnni3k kinase activity. Thus, in several species, natural Tnni3k polymorphisms exist that are predicted to contribute to variation in diploid CM level and heart regenerative ability.<br />Competing Interests: The authors declare that there are no conflicts of interest present.<br /> (Copyright: © 2024 by the authors.)
Details
- Language :
- English
- ISSN :
- 2578-9430
- Volume :
- 2024
- Database :
- MEDLINE
- Journal :
- MicroPublication biology
- Publication Type :
- Academic Journal
- Accession number :
- 38828440
- Full Text :
- https://doi.org/10.17912/micropub.biology.001164