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Intraprostatic hormone dosage: Validation of a novel prostate biopsy technique.
- Source :
-
The French journal of urology [Fr J Urol] 2024 Jul; Vol. 34 (7-8), pp. 102659. Date of Electronic Publication: 2024 May 31. - Publication Year :
- 2024
-
Abstract
- Background: Advances in chromatography and mass spectrometry have allowed us to develop a novel technique for measuring intraprostatic hormone concentrations directly on prostate needle biopsies, rather than using traditional punch excision. This has significant clinical implications as intraprostatic dihydrotestosterone and testosterone levels could help monitor prostate growth, neoplasia and castration resistance.<br />Methods: Patients undergoing radical cystoprostatectomy for bladder cancer were prospectively included. Each prostate specimen received one 90mg punch excision and six needle biopsies. Intraprostatic hormones were dosed through gas chromatography-mass spectrometry.<br />Results: We included twenty patients, of which eleven were incidentally diagnosed with prostate cancer; four had ISUP 1 (20%) and seven had ISUP 2 (35%). The prostate biopsy technique was unable to obtain measures for testosterone, Delta-4-androsterone and androstenedione. Tissue concentrations of DHEA, DHT, E1 and E2 can be obtained with no significant difference from the reference established on a punch from a single biopsy core sample.<br />Conclusions: Our study demonstrates that intraprostatic concentrations of DHEA, DHT, E1 and E2 can be measured without significant difference from the reference established on a single punch excision. This finding opens the way to research on the interactions between endocrinology and prostate oncogenesis and particularly on the mechanisms of resistance to hormone therapies in vivo.<br /> (Copyright © 2024 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Humans
Male
Aged
Middle Aged
Prospective Studies
Gas Chromatography-Mass Spectrometry methods
Dihydrotestosterone metabolism
Dehydroepiandrosterone analysis
Dehydroepiandrosterone administration & dosage
Biopsy, Needle methods
Testosterone analysis
Estradiol analysis
Prostatic Neoplasms pathology
Prostatic Neoplasms surgery
Prostate pathology
Prostate surgery
Prostate metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2950-3930
- Volume :
- 34
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- The French journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 38825320
- Full Text :
- https://doi.org/10.1016/j.fjurol.2024.102659