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Intraprostatic hormone dosage: Validation of a novel prostate biopsy technique.

Authors :
Pattou M
Neuzillet Y
Raynaud JP
Radulescu C
Fiet J
Giton F
Labro M
Lebret T
Botto H
Source :
The French journal of urology [Fr J Urol] 2024 Jul; Vol. 34 (7-8), pp. 102659. Date of Electronic Publication: 2024 May 31.
Publication Year :
2024

Abstract

Background: Advances in chromatography and mass spectrometry have allowed us to develop a novel technique for measuring intraprostatic hormone concentrations directly on prostate needle biopsies, rather than using traditional punch excision. This has significant clinical implications as intraprostatic dihydrotestosterone and testosterone levels could help monitor prostate growth, neoplasia and castration resistance.<br />Methods: Patients undergoing radical cystoprostatectomy for bladder cancer were prospectively included. Each prostate specimen received one 90mg punch excision and six needle biopsies. Intraprostatic hormones were dosed through gas chromatography-mass spectrometry.<br />Results: We included twenty patients, of which eleven were incidentally diagnosed with prostate cancer; four had ISUP 1 (20%) and seven had ISUP 2 (35%). The prostate biopsy technique was unable to obtain measures for testosterone, Delta-4-androsterone and androstenedione. Tissue concentrations of DHEA, DHT, E1 and E2 can be obtained with no significant difference from the reference established on a punch from a single biopsy core sample.<br />Conclusions: Our study demonstrates that intraprostatic concentrations of DHEA, DHT, E1 and E2 can be measured without significant difference from the reference established on a single punch excision. This finding opens the way to research on the interactions between endocrinology and prostate oncogenesis and particularly on the mechanisms of resistance to hormone therapies in vivo.<br /> (Copyright © 2024 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Details

Language :
English
ISSN :
2950-3930
Volume :
34
Issue :
7-8
Database :
MEDLINE
Journal :
The French journal of urology
Publication Type :
Academic Journal
Accession number :
38825320
Full Text :
https://doi.org/10.1016/j.fjurol.2024.102659