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Transcriptomic and genomic characteristics of intrahepatic metastases of primary liver cancer.
- Source :
-
BMC cancer [BMC Cancer] 2024 Jun 01; Vol. 24 (1), pp. 672. Date of Electronic Publication: 2024 Jun 01. - Publication Year :
- 2024
-
Abstract
- Background: Patients with primary multifocal hepatocellular carcinoma (HCC) have a poor prognosis and often experience a high rate of treatment failure. Multifocal HCC is mainly caused by intrahepatic metastasis (IM), and though portal vein tumor thrombosis (PVTT) is considered a hallmark of IM, the molecular mechanism by which primary HCC cells invade the portal veins remains unclear. Therefore, it is necessary to recognize the early signs of metastasis of HCC to arrange better treatment for patients.<br />Results: To determine the differential molecular features between primary HCC with and without phenotype of metastasis, we used the CIBERSORTx software to deconvolute cell types from bulk RNA-Seq based on a single-cell transcriptomic dataset. According to the relative abundance of tumorigenic and metastatic hepatoma cells, VEGFA <superscript>+</superscript> macrophages, effector memory T cells, and natural killer cells, HCC samples were divided into five groups: Pro-T, Mix, Pro-Meta, NKC, and MemT, and the transcriptomic and genomic features of the first three groups were analyzed. We found that the Pro-T group appeared to retain native hepatic metabolic activity, whereas the Pro-Meta group underwent dedifferentiation. Genes highly expressed in the group Pro-Meta often signify a worse outcome.<br />Conclusions: The HCC cohort can be well-typed and prognosis predicted according to tumor microenvironment components. Primary hepatocellular carcinoma may have obtained corresponding molecular features before metastasis occurred.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Prognosis
Genomics methods
Gene Expression Regulation, Neoplastic
Gene Expression Profiling
Male
Female
Killer Cells, Natural metabolism
Killer Cells, Natural immunology
Liver Neoplasms genetics
Liver Neoplasms secondary
Liver Neoplasms pathology
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular pathology
Carcinoma, Hepatocellular secondary
Tumor Microenvironment genetics
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 38824541
- Full Text :
- https://doi.org/10.1186/s12885-024-12428-x