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The joint action of yeast eisosomes and membraneless organelles in response to ethanol stress.

Authors :
Pinto CM
Schnepper AP
Trindade PHE
Cardoso LH
Fioretto MN
Justulin LA
Zanelli CF
Valente GT
Source :
Heliyon [Heliyon] 2024 May 19; Vol. 10 (10), pp. e31561. Date of Electronic Publication: 2024 May 19 (Print Publication: 2024).
Publication Year :
2024

Abstract

Elevated ethanol concentrations in yeast affect the plasma membrane. The plasma membrane in yeast has many lipid-protein complexes, such as Pma1 (MCP), Can1 (MCC), and the eisosome complex. We investigated the response of eisosomes, MCPs, and membraneless structures to ethanol stress. We found a correlation between ethanol stress and proton flux with quick acidification of the medium. Moreover, ethanol stress influences the symporter expression in stressed cells. We also suggest that acute stress from ethanol leads to increases in eisosome size and SG number: we hypothesized that eisosomes may protect APC symporters and accumulate an mRNA decay protein in ethanol-stressed cells. Our findings suggest that the joint action of these factors may provide a protective effect on cells under ethanol stress.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2024 The Authors. Published by Elsevier Ltd.)

Details

Language :
English
ISSN :
2405-8440
Volume :
10
Issue :
10
Database :
MEDLINE
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
38818138
Full Text :
https://doi.org/10.1016/j.heliyon.2024.e31561