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Disseminated intravascular coagulation is associated with poor prognosis in patients with COVID-19.
- Source :
-
Scientific reports [Sci Rep] 2024 May 30; Vol. 14 (1), pp. 12443. Date of Electronic Publication: 2024 May 30. - Publication Year :
- 2024
-
Abstract
- This study aimed to investigate the incidence and significance of disseminated intravascular coagulation (DIC) in coronavirus disease 2019 (COVID-19). A multicenter cohort study was conducted using large-scale COVID-19 registry data. The patients were classified into DIC and non-DIC groups based on the diagnosis on admission (day 1) and on any of the days 1, 4, 8, and 15. In total, 23,054 patients were divided into DIC (nā=ā264) and non-DIC (nā=ā22,790) groups on admission. Thereafter, 1654 patients were divided into 181 patients with DIC and 1473 non-DIC patients based on the DIC diagnosis on any of the days from 1 to 15. DIC incidence was 1.1% on admission, increasing to 10.9% by day 15. DIC diagnosis on admission had moderate predictive performance for developing multiple organ dysfunction syndrome (MODS) on day 4 and in-hospital death and was independently associated with MODS and in-hospital death. DIC diagnosis on any of the days from 1 to 15, especially days 8 and 15, was associated with lower survival probability than those without DIC and showed significant association with in-hospital death. In conclusion, despite its low incidence, DIC, particularly late-onset DIC, plays a significant role in the pathogenesis of poor prognosis in patients with COVID-19.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Prognosis
Middle Aged
Aged
Incidence
SARS-CoV-2 isolation & purification
Hospital Mortality
Multiple Organ Failure mortality
Multiple Organ Failure etiology
Adult
Aged, 80 and over
Disseminated Intravascular Coagulation mortality
COVID-19 mortality
COVID-19 complications
COVID-19 epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38816405
- Full Text :
- https://doi.org/10.1038/s41598-024-63078-9