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The Application of 2d Mxene Nanosheet -Based Thermosensitive Gel Delivery System Loaded with Cisplatin and Imiquimod for Lung Cancer.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2024 May 25; Vol. 19, pp. 4719-4733. Date of Electronic Publication: 2024 May 25 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Introduction: Lung cancer's high incidence and dismal prognosis with traditional treatments like surgery and radiotherapy necessitate innovative approaches. Despite advancements in nanotherapy, the limitations of single-treatment modalities and significant side effects persist. To tackle lung cancer effectively, we devised a temperature-sensitive hydrogel-based local injection system with near-infrared triggered drug release. Utilizing 2D MXene nanosheets as carriers loaded with R837 and cisplatin (DDP), encapsulated within a temperature-sensitive hydrogel-forming PEG-MXene@DDP@R837@SHDS (MDR@SHDS), we administered in situ injections of MDR@SHDS into tumor tissues combined with photothermal therapy (PTT). The immune adjuvant R837 enhances dendritic cell (DC) maturation and tumor cell phagocytosis, while PTT induces tumor cell apoptosis and necrosis by converting light energy into heat energy.<br />Methods: Material characterization employed transmission electron microscopy, X-ray photoelectron spectroscopy, phase transition temperature, and near-infrared thermography. In vitro experiments assessed Lewis cell proliferation and apoptosis using CCK-8, Edu, and TUNEL assays. In vivo experiments on C57 mouse Lewis transplant tumors evaluated the photothermal effect via near-infrared thermography and assessed DC maturation and CD4+/CD8+ T cell ratios using flow cytometry. The in vivo anti-tumor efficacy of MDR@SHDS was confirmed by tumor growth curve recording and HE and TUNEL staining of tumor sections.<br />Results: The hydrogel exhibited excellent temperature sensitivity, controlled release properties, and high biocompatibility. In vitro experiments revealed that MDR@SHDS combined with PTT had a greater inhibitory effect on tumor cell proliferation compared to MDR@SHD alone. Combining local immunotherapy, chemotherapy, and PTT yielded superior anti-tumor effects than individual treatments.<br />Conclusion: MDR@SHDS, with its simplicity, biocompatibility, and enhanced anti-tumor effects in combination with PTT, presents a promising therapeutic approach for lung cancer treatment, offering potential clinical utility.<br />Competing Interests: The authors report no conflicts of interest in this work.<br /> (© 2024 Ma et al.)
- Subjects :
- Animals
Mice
Hydrogels chemistry
Apoptosis drug effects
Nanostructures chemistry
Photothermal Therapy methods
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents administration & dosage
Cell Line, Tumor
Drug Delivery Systems methods
Humans
Temperature
Dendritic Cells drug effects
Drug Carriers chemistry
Carcinoma, Lewis Lung drug therapy
Carcinoma, Lewis Lung pathology
Cisplatin pharmacology
Cisplatin chemistry
Cisplatin administration & dosage
Lung Neoplasms drug therapy
Lung Neoplasms pathology
Imiquimod chemistry
Imiquimod administration & dosage
Imiquimod pharmacology
Mice, Inbred C57BL
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 19
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 38813391
- Full Text :
- https://doi.org/10.2147/IJN.S449541