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Dapagliflozin mitigates oxidative stress, inflammatory, and histopathological markers of aging in mice.
- Source :
-
Journal of medicine and life [J Med Life] 2024 Feb; Vol. 17 (2), pp. 157-163. - Publication Year :
- 2024
-
Abstract
- Aging, a complex physiological process affecting all living things, is a major area of research, particularly focused on interventions to slow its progression. This study assessed the antiaging efficacy of dapagliflozin (DAPA) on various aging-related parameters in a mouse model artificially induced to age. Forty male Swiss albino mice were randomly divided into four groups of ten animals each. The control group (Group I) received normal saline. The aging model group (Group II) was administered D-galactose orally at 500mg/kg to induce aging. Following the aging induction, the positive control group received Vitamin C supplementation (Group III), while the DAPA group (Group IV) was treated with dapagliflozin. The inflammatory mediators (TNF-α and IL-1β) showed similar patterns of change. No statistically significant difference was observed between groups III and IV. Both groups had significantly lower values compared to GII, while it was significantly higher compared to GI. Glutathione peroxidase (GSH-Px) showed no statistically significant difference between groups GIII and GIV, but it was higher in GIII compared to GII and significantly lower in GIII compared to GI. The study demonstrated that dapagliflozin exerts a beneficial impact on many indicators of aging in mice. The intervention resulted in a reduction in hypertrophy in cardiomyocytes, an enhancement in skin vitality, a decrease in the presence of inflammatory mediators, and an improvement in the efficacy of antioxidants.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2024 by the authors.)
- Subjects :
- Animals
Mice
Male
Biomarkers metabolism
Tumor Necrosis Factor-alpha metabolism
Interleukin-1beta metabolism
Benzhydryl Compounds pharmacology
Benzhydryl Compounds therapeutic use
Glucosides pharmacology
Glucosides therapeutic use
Oxidative Stress drug effects
Aging drug effects
Aging pathology
Inflammation drug therapy
Inflammation pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1844-3117
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of medicine and life
- Publication Type :
- Academic Journal
- Accession number :
- 38813367
- Full Text :
- https://doi.org/10.25122/jml-2023-0343