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Subgenomic flavivirus RNA as key target for live-attenuated vaccine development.
- Source :
-
Journal of virology [J Virol] 2024 Jul 23; Vol. 98 (7), pp. e0010023. Date of Electronic Publication: 2024 May 29. - Publication Year :
- 2024
-
Abstract
- Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.<br />Competing Interests: The authors declare no conflict of interest.
Details
- Language :
- English
- ISSN :
- 1098-5514
- Volume :
- 98
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 38808973
- Full Text :
- https://doi.org/10.1128/jvi.00100-23