Back to Search
Start Over
Lipid Profile and Atherogenic Risk Assessment in Nigerian Breast Cancer Patients - A Cross-Sectional Study.
- Source :
-
Journal of the American Nutrition Association [J Am Nutr Assoc] 2024 Sep-Oct; Vol. 43 (7), pp. 582-591. Date of Electronic Publication: 2024 May 28. - Publication Year :
- 2024
-
Abstract
- Background: The lipid profile and atherogenic risk indices in Nigerian breast cancer patients are largely unknown. This study evaluated the lipid profile and atherogenic risk indices of breast cancer patients in Nigeria.<br />Methods: This study involved 45 primarily diagnosed breast cancer patients and 50 normal control subjects. Total cholesterol, triglyceride, and High-density lipoprotein cholesterol (HDL-C) were measured. Low-density lipoprotein cholesterol (LDL-C) was calculated according to Friedewald formula. Atherogenic index of plasma (AIP), Atherogenic coefficient (AC), TC/HDL-C (Castelli I) and LDL-C/HDL-C (Castelli II) risk indices were all calculated. The Framingham risk assessment was calculated and categorized.<br />Results: The study group had significantly higher triglycerides (TG), and atherogenic indices than the control group ( p < 0.001), while HDL-Cholesterol (HDL-C) was significantly lower in the study group ( p < 0.001). Total cholesterol and LDL-Cholesterol (LDL-C) had a significant positive correlation with age ( r = 0.283, p < 0.018; r = 0.272, p < 0.023); TG was significantly positively correlated with systolic and diastolic blood pressure ( r = 0.320. p < 0.007; r = 0.334, p < 0.005); HDL-C had a significant negative correlation with BMI, systolic and diastolic blood pressure ( r = -0.252, p < 0.035; r = -0.29, p < 0.015; r = -0.329, p < 0.005). The lipid ratios (TC/HDL-C, LDL-C/HDL-C) were significantly positively correlated with body mass index (BMI), systolic and diastolic blood pressure. The Framingham Risk Score showed that only 2 subjects in the study group (4.4%) were at a high risk of having a cardiovascular event.<br />Conclusion: Breast cancer patients have a higher prevalence of dyslipidaemia, and cardiovascular risk than the normal population.
- Subjects :
- Humans
Female
Nigeria epidemiology
Middle Aged
Cross-Sectional Studies
Adult
Risk Assessment
Risk Factors
Blood Pressure
Lipids blood
Aged
Body Mass Index
Breast Neoplasms blood
Breast Neoplasms epidemiology
Atherosclerosis blood
Atherosclerosis epidemiology
Atherosclerosis diagnosis
Atherosclerosis etiology
Triglycerides blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Subjects
Details
- Language :
- English
- ISSN :
- 2769-707X
- Volume :
- 43
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of the American Nutrition Association
- Publication Type :
- Academic Journal
- Accession number :
- 38805002
- Full Text :
- https://doi.org/10.1080/27697061.2024.2353289