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Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflurane Anesthesia for Pediatric Liver Surgery.
- Source :
-
Annals of transplantation [Ann Transplant] 2024 May 28; Vol. 29, pp. e943281. Date of Electronic Publication: 2024 May 28. - Publication Year :
- 2024
-
Abstract
- BACKGROUND We aimed to assess the effect of dexmedetomidine (Dex) combined with remifentanil on emergence agitation (EA) during awakening from sevoflurane anesthesia for pediatric liver surgery. MATERIAL AND METHODS Sixty children who underwent liver surgery in our hospital were prospectively selected and randomly allocated into group A (placebo+remifentanil+sevoflurane) or group B (Dex+remifentanil+sevoflurane). Mean arterial pressure (MAP) and heart rate (HR) at different time points, agitation score during awakening, behavioral status, pain level, and the incidence of postoperative adverse effects were compared in both groups. RESULTS Children in group B had lower HR and MAP levels immediately after tracheal extubation and 5 min after tracheal extubation than those in group A. The Aono's scores, PAED agitation scores, and CHIPP scores at 15 min and 30 min of admission to the PACU were lower in group B than in group A. The incidence of agitation during postoperative anesthesia awakening was lower in group B in contrast to group A. There was no significant difference in postoperative adverse reactions between group A and group B. CONCLUSIONS In pediatric liver surgery, the use of Dex+remifentanil+sevoflurane anesthesia can reduce the incidence of EA during the awakening period, stabilize hemodynamic levels, and relieve postoperative pain, and has fewer postoperative adverse effects, which warrants clinical application.
- Subjects :
- Humans
Female
Male
Child, Preschool
Prospective Studies
Hypnotics and Sedatives administration & dosage
Hypnotics and Sedatives therapeutic use
Infant
Child
Psychomotor Agitation prevention & control
Psychomotor Agitation etiology
Liver surgery
Anesthesia Recovery Period
Piperidines administration & dosage
Piperidines therapeutic use
Piperidines adverse effects
Double-Blind Method
Drug Therapy, Combination
Methyl Ethers administration & dosage
Methyl Ethers adverse effects
Analgesics, Opioid administration & dosage
Analgesics, Opioid therapeutic use
Dexmedetomidine administration & dosage
Dexmedetomidine therapeutic use
Remifentanil administration & dosage
Remifentanil therapeutic use
Sevoflurane administration & dosage
Anesthetics, Inhalation administration & dosage
Anesthetics, Inhalation adverse effects
Emergence Delirium prevention & control
Emergence Delirium etiology
Emergence Delirium epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2329-0358
- Volume :
- 29
- Database :
- MEDLINE
- Journal :
- Annals of transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 38803088
- Full Text :
- https://doi.org/10.12659/AOT.943281