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JNK signaling and its impact on neural cell maturation and differentiation.

Authors :
Castro-Torres RD
Olloquequi J
Parcerisas A
Ureña J
Ettcheto M
Beas-Zarate C
Camins A
Verdaguer E
Auladell C
Source :
Life sciences [Life Sci] 2024 Aug 01; Vol. 350, pp. 122750. Date of Electronic Publication: 2024 May 25.
Publication Year :
2024

Abstract

C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies and cancer progression. However, JNKs serve key roles under physiological conditions, particularly within the central-nervous-system (CNS), where they are critical in governing neural proliferation and differentiation during both embryogenesis and adult stages. These processes control the development of CNS, avoiding neurodevelopment disorders. JNK are key to maintain the proper activity of neural-stem-cells (NSC) and neural-progenitors (NPC) that exist in adults, which keep the convenient brain plasticity and homeostasis. This review underscores how the interaction of JNK with upstream and downstream molecules acts as a regulatory mechanism to manage the self-renewal capacity and differentiation of NSC/NPC during CNS development and in adult neurogenic niches. Evidence suggests that JNK is reliant on non-canonical Wnt components, Fbw7-ubiquitin-ligase, and WDR62-scaffold-protein, regulating substrates such as transcription factors and cytoskeletal proteins. Therefore, understanding which pathways and molecules interact with JNK will bring knowledge on how JNK activation orchestrates neuronal processes that occur in CNS development and brain disorders.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interest.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1879-0631
Volume :
350
Database :
MEDLINE
Journal :
Life sciences
Publication Type :
Academic Journal
Accession number :
38801982
Full Text :
https://doi.org/10.1016/j.lfs.2024.122750