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Epidemiological characteristics of human metapneumovirus among children in Nanjing, China.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2024 Jul; Vol. 43 (7), pp. 1445-1452. Date of Electronic Publication: 2024 May 27. - Publication Year :
- 2024
-
Abstract
- Purpose: The objective of this study was to examine the molecular epidemiology and clinical characteristics of HMPV infection among children with ARIs in Nanjing.<br />Methods: The respiratory samples were collected from 2078 children (≤ 14 years) with acute respiratory infections and were tested for HMPV using real-time RT-PCR. Amplification and sequencing of the HMPV G gene were followed by phylogenetic analysis using MEGA 7.0.<br />Result: The detection rate of HMPV among children was 4.7% (97/2078), with a concentration in those under 5 years of age. Notably, the peak season for HMPV prevalence was observed in winter. Among the 97 HMPV-positive samples, 51.5% (50/97) were available for characterization of the HMPV G protein gene. Phylogenetic analysis indicated that the sequenced HMPV strains were classified into three sublineages: A2c <subscript>111nt - dup</subscript> (84.0%), B1 (2.0%), and B2 (14.0%).<br />Conclusion: There was an incidence of HMPV among hospitalized children during 2021-2022 in Nanjing with A2c <subscript>111nt - dup</subscript> being the dominant strain. This study demonstrated the molecular epidemiological characteristics of HMPV among children with respiratory infections in Nanjing, China.<br /> (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Humans
China epidemiology
Child, Preschool
Child
Infant
Male
Female
Adolescent
Incidence
Infant, Newborn
Prevalence
Genotype
Metapneumovirus genetics
Metapneumovirus classification
Metapneumovirus isolation & purification
Paramyxoviridae Infections epidemiology
Paramyxoviridae Infections virology
Phylogeny
Respiratory Tract Infections epidemiology
Respiratory Tract Infections virology
Molecular Epidemiology
Seasons
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 43
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 38801487
- Full Text :
- https://doi.org/10.1007/s10096-024-04858-z