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T-Cell redirecting bispecific antibodies: a review of a novel class of immuno-oncology for advanced prostate cancer.
- Source :
-
Cancer biology & therapy [Cancer Biol Ther] 2024 Dec 31; Vol. 25 (1), pp. 2356820. Date of Electronic Publication: 2024 May 27. - Publication Year :
- 2024
-
Abstract
- Novel T-cell immunotherapies such as bispecific T-cell engagers (BiTEs) are emerging as promising therapeutic strategies for prostate cancer. BiTEs are engineered bispecific antibodies containing two distinct binding domains that allow for concurrent binding to tumor-associated antigens (TAAs) as well as immune effector cells, thus promoting an immune response against cancer cells. Prostate cancer is rich in tumor associated antigens such as, but not limited to, PSMA, PSCA, hK2, and STEAP1 and there is strong biologic rationale for employment of T-cell redirecting BiTEs within the prostate cancer disease space. Early generation BiTE constructs employed in clinical study have demonstrated meaningful antitumor activity, but challenges related to drug delivery, immunogenicity, and treatment-associated adverse effects limited their success. The ongoing development of novel BiTE constructs continues to address these barriers and to yield promising results in terms of efficacy and safety. This review will highlight some of most recent developments of BiTE therapies for patients with advanced prostate cancer and the evolving data surrounding BiTE constructs undergoing clinical evaluation.
- Subjects :
- Humans
Male
Antigens, Neoplasm immunology
Animals
Antibodies, Bispecific therapeutic use
Antibodies, Bispecific pharmacology
Antibodies, Bispecific immunology
Prostatic Neoplasms immunology
Prostatic Neoplasms therapy
Prostatic Neoplasms drug therapy
Prostatic Neoplasms pathology
T-Lymphocytes immunology
Immunotherapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1555-8576
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer biology & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 38801069
- Full Text :
- https://doi.org/10.1080/15384047.2024.2356820