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Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: The role of prelimbic neocortex-hippocampal connections.

Authors :
Medeiros AC
Medeiros P
Pigatto GR
Maione S
Coimbra NC
de Freitas RL
Source :
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2024 Aug 30; Vol. 134, pp. 111039. Date of Electronic Publication: 2024 May 24.
Publication Year :
2024

Abstract

Background and Purpose: Chronic neuropathic pain (NP) is commonly associated with cognitive and emotional impairments. Cannabidiol (CBD) presents a broad spectrum of action with a potential analgesic effect. This work investigates the CBD effect on comorbidity between chronic NP, depression, and memory impairment.<br />Experimental Approach: The connection between the neocortex and the hippocampus was investigated with biotinylated dextran amine (BDA) deposits in the prelimbic cortex (PrL). Wistar rats were submitted to chronic constriction injury (CCI) of the sciatic nerve and CA <subscript>1</subscript> treatment with CBD (15, 30, 60 nmol).<br />Key Results: BDA-labeled perikarya and terminal buttons were found in CA <subscript>1</subscript> and dentate gyrus. CCI-induced mechanical and cold allodynia increased c-Fos protein expression in the PrL and CA <subscript>1</subscript> . The number of astrocytes in PrL and CA <subscript>1</subscript> increased, and the number of neuroblasts decreased in CA <subscript>1</subscript> . Animals submitted to CCI procedure showed increasing depressive-like behaviors, such as memory impairment. CBD (60 nmol) treatment decreased mechanical and cold allodynia, attenuated depressive-associated behaviors, and improved memory performance. Cobalt chloride (CoCl <subscript>2</subscript> : 1 nM), WAY-100635 (0.37 nmol), and AM251 (100 nmol) intra-PrL reversed the effect of CA <subscript>1</subscript> treatment with CBD (60 nmol) on nociceptive, cognitive, and depressive behaviors.<br />Conclusion: CBD represents a promising therapeutic perspective in the pharmacological treatment of chronic NP and associated comorbidities such as depression and memory impairments. The CBD effects possibly recruit the CA <subscript>1</subscript> -PrL pathway, inducing neuroplasticity. CBD acute treatment into the CA <subscript>1</subscript> produces functional and molecular morphological improvements.<br />Competing Interests: Declaration of competing interest The authors declare no conflicts of interest concerning the work presented herein.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1878-4216
Volume :
134
Database :
MEDLINE
Journal :
Progress in neuro-psychopharmacology & biological psychiatry
Publication Type :
Academic Journal
Accession number :
38797491
Full Text :
https://doi.org/10.1016/j.pnpbp.2024.111039