Targeted i 6 A-RNA degradation through sequential Fluorination-Azidation and Click reaction with imidazole-based probes.

We report the use of trimethylsilyl azide and Selectfluor to implement a standard protocol targeted at the prenylated nucleic acid known as i ⁶ A-RNA. After optimizing the conditions, we applied this method to regulate a wide range of i ⁶ A-RNA species using synthetic imidazole-based probes (I-IV). We observed that prenylated nucleic acid plays a crucial role in the cell hemostasis in A549 cell lines.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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